The team lead by Joshua M. Shulman at the Laboratory for Integrative Functional Genomics has published a paper reporting on human genetic analyses, revealing connections between genes and the risk of Parkinson’s disease.
Published in Brain: A Journal of Neurology, “Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease,” reports that mutations in the glucocerebrosidase gene (GBA), which causes Gaucher disease, may be risk factors for Parkinson’s:
“Our results highlight several promising new susceptibility loci and reinforce the importance of lysosomal mechanisms in Parkinson’s disease pathogenesis. We suggest that multiple genetic hits may act in combination to degrade lysosomal function, enhancing Parkinson’s disease susceptibility.”
Principal Investigator and Associate Professor
Departments of Neurology, Molecular and Human Genetics, Neuroscience and Program in Developmental Biology
Baylor College of Medicine
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Laboratory for Integrative Functional Genomics
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